Zogulitsa
Doxifluridine
Zomangamanga Formula
Zakuthupi
Maonekedwe: White Solid
Kachulukidwe: 1.3751 (chiwerengero)
Malo osungunuka: 188-192 °c (lit.)
Kuzungulira Kwapadera:d25 +18.4° (c = 0.419 M'madzi)
Refractivity: 20 °(c=1, H2o)
Malo Osungira: Inert Atmosphere, Kutentha kwachipinda
Acidity Factor(pka): 7.4 (pa 25 ℃)
Data Data
Gulu lowopsa:Sizinthu zowopsa
Nambala yonyamula katundu wowopsa:
Gulu lazopaka:
Kugwiritsa ntchito
1. Monga mankhwala a 5-Flurouridine.A fluorinated pyrimidine nucleoside ndi cytostatic ntchito.Mankhwala omwe amagwiritsidwa ntchito pa khansa ya m'mimba, khansa ya m'mimba, khansa ya m'mawere, chikhululukiro chikhoza kufika kupitirira 30%
2. Monga wapakatikati kwa Fluorouracil antitumor mankhwala
Chidziwitso cha ogwiritsa ntchito
1. Fluorouracil-based antitumour agents ndi kalambulabwalo wa fluorouracil.Enzyme thymidine phosphorylase, yomwe imapezeka m'minyewa yotupa, imagwirapo ntchito kuti isinthe kukhala fluorouracil mu chotupacho, motero imakhala ndi anti-chotupa.Ili ndi mphamvu yotsutsana ndi chotupa komanso kawopsedwe kakang'ono.Amagwiritsidwa ntchito pochiza khansa ya m'mimba, khansa ya m'mimba ndi khansa ya m'mawere, ndi chikhululukiro chofikira 30% kapena kuposa.
2. Mankhwala apakatikati.
3. Ndi antitumour wothandizira, mankhwala otsogolera a fluorouracil (5-FU), omwe amasandulika kukhala fluorouracil yaulere ndi zochita za pyrimidine nucleoside phosphorylase m'matumbo a chotupa, motero amalepheretsa biosynthesis ya DNA ndi RNA m'maselo a chotupa ndikuwonetsa antitumor zotsatira.Popeza zochita za enzymeyi ndizokwera kwambiri m'matumbo a chotupa kuposa momwe zimakhalira, kusintha kwa 5-FU kukhala 5-FU m'matumbo a chotupa kumakhala kofulumira komanso kosankha zotupa.Amagwiritsidwa ntchito pochiza khansa ya m'mawere, m'mimba ndi rectum ndipo ali ndi kawopsedwe kakang'ono.
