Zogulitsa
2,6-Di-tert-butyl-4-methylpyridine
Zomangamanga Formula
Maonekedwe: kristalo woyera acicular
Kulemera kwake: 1,476 g/cm3
Malo osungunuka: 31-32 ℃
Malo otentha: 148-153 ℃ (12.6kPa)
Refractive index: N20 /D 1.4763 (lit.)
Pothirira: 183 °F
Kusungirako: 2-8°C
Acidity coefficient (pKa): 6.88±0.10(Zonenedweratu)
Data Data
Ndi ya general cargo
Customs kodi: 2942000000
Mtengo wochotsera msonkho wa kunja (%): 13%
Kugwiritsa ntchito
Organic synthetic intermediate, yotchinga mwamphamvu, yopanda nucleophilic maziko yomwe imasiyanitsa pakati pa Brnsted (protonic) ndi Lewis acids.Imathandizira kusintha kwachindunji kwa zokolola zambiri za aldehydes1 ndi ketoni1,2 kukhala ma vinyl triflates.
2,6-Di-tert-butyl-4-methylpyridine ndi organic pawiri ndi maselo chilinganizo C14H23N, yofunika wapakatikati mu kaphatikizidwe organic, makamaka ntchito intermediates mankhwala, kaphatikizidwe organic, organic solvents, komanso angagwiritsidwe ntchito kupanga utoto, mankhwala ophera tizilombo. kupanga ndi zonunkhira, etc.
Njira yopangira
1. Pangani 2,6 di-tert-butyl-4-methylbenzyl trifluoromethanesulfonate Mu botolo la 100-mL katatu lomwe lili ndi chubu loyambitsira nayitrojeni, chubu champhamvu chokhazikika, kapu ya electromagnetic yosonkhezera ndi madzi oundana okhala ndi chubu youma, onjezerani 24.2 g (0.2 mol) wa trimethylethyl phthalide chloride ndi 3.7 g (0.05 mol) wa tert-butanol.Chosakanizacho chinatenthedwa mu mafuta osamba mpaka 85 ° C.Kenako 15 g (0.1 mol) wa trifluoromethanesulfonic acid adawonjezeredwa kwa mphindi zopitilira 15.Zomwezo zidapitilira kwa mphindi 10, ndipo chinthu chopepuka cha bulauni chidakhazikika mumadzi osambira ndikutsanulira mu 100 ml ya ether yozizira.Madzi a bulauni adasefedwa ndikuwumitsidwa kuti apeze 9.6 g (54%) ya mchere wochedwetsedwa.(Palibe kuyeretsedwa komwe kumafunikira: pa sitepe yotsatira yokonzekera, wiritsaninso kawiri kuchokera ku chloroform kupita ku carbon tetrachloride 3:1) kupita ku makhiristo opanda mtundu onga singano.
2. Kukonzekera kwa 2,6-Di-tert-butyl-4-methyl-vizine Pogwedezeka, kuyimitsidwa kwa 10 g (0.028 mol) ya mchere wa vizine mu 200 mL wa 95% ethanol wozizira mpaka 60 ° C kunali onjezerani kamodzi ku 100 mL wa ammonia wokhazikika wozizira mpaka 60 ° C mu botolo la 1 lita imodzi ya dimba-pansi.Zomwezo zinapitilira pa 60 ° C kwa mphindi 30 ndi 40 ° C kwa maola 2, panthawi yomwe kuyimitsidwa kunasungunuka.Kenako, zimene osakaniza anathiridwa 500 ml ya 2% sodium hydroxide njira pang`onopang`ono analimbikitsa ndi firiji.Yotengedwa ndi .4-100 ml ya pentane, kuphatikiza akupanga, 25 ml ya ano zimalimbikitsa sodium kolorayidi njira kutsukidwa, 100 ml ya pentane wozungulira evaporator ndende.
