Zogulitsa
Polyinosinic Acid-polycytidylic Acid
Zomangamanga Formula
Zakuthupi
Maonekedwe: ufa woyera kapena woyera
Kuchulukana.
Malo osungunuka.
Malo otentha.
Refractivity
Pophulikira.
Data Data
Gulu lowopsa.
Nambala Yoyendetsa Katundu Woopsa.
Wonyamula gulu.
Kugwiritsa ntchito
Poly I:C amadziwika kuti amalumikizana ndi toll-like receptor 3 (TLR3), yomwe imawonetsedwa pa endosomal nembanemba ya B-maselo, macrophages ndi ma cell a dendritic.Poly I:C ndi yofanana ndi RNA yamitundu iwiri, yomwe imapezeka m'ma virus ena ndipo ndi "chilengedwe" cholimbikitsa cha TLR3.Chifukwa chake, Poly I: C imatha kuonedwa ngati analogi yopangidwa ndi RNA yokhala ndi zingwe ziwiri ndipo ndi chida chodziwika bwino pakufufuza kwasayansi pachitetezo cha chitetezo chamthupi.
Khalidwe
Izi ndi zopangira interferon inducer, zomwe ndi polyribonucleotide yopangidwa ndi polyinosinic acid ndi polycytidylic acid.Popeza kuti interferon ndi yeniyeni ya zamoyo, zimakhala zovuta kukonzekera zochulukirapo kuti zigwiritsidwe ntchito kuchipatala, choncho zimagwiritsidwa ntchito kwambiri ngati interferon inducer kuti apange interferon.Komanso, asidi polyinosinic akadali ndi udindo wa chitetezo adjuvant, amene angathe kulimbikitsa dongosolo reticuloendothelial, kumapangitsanso phagocytic ntchito phagocytes, kumapangitsanso mapangidwe akupha, yotithandiza allograft anachita ndi kuchedwa thupi lawo siligwirizana.Imakhala ndi antiviral ndi antitumor effect.
Ntchito ndi kaphatikizidwe njira
Mwachidule
Polycytidylic acid, yomwe imadziwikanso kuti polyinosinic acid, polyhypoxanthine nucleotide ndi polycytidine nucleotide, ndi imodzi mwa polynucleotides, yomwe imakhala ndi unyolo wa polynucleotide wa polyinosinic acid ndi polycytidylic acid, wokhala ndi decolorization ndi malo osungunuka, ndi 20 ℃. .
Zotsatira za Pharmacological
1. Polyinosinic acid imakhala ndi zotsatira zabwino zolimbikitsira chitetezo chokwanira komanso chosakhazikika cha thupi.
(1) Ma polymyocyte amawonjezera ntchito za maselo oteteza thupi
(2) Ma polymyocytes amalimbikitsa kutulutsa kwa ma cytokines osiyanasiyana
(3) Kulowetsedwa kwa mapuloteni a Mx ndi polymyocytes
(4) Ma polymyocyte amalimbikitsa kupanga ma antibodies mu vivo
2. Anti-viral zotsatira za polymyocytes
Mayeso a in vitro, kuyesa kwa nyama ndi kuyesa kwachipatala kwa anthu atsimikizira kuti ma polymyxins ali ndi zotsatira zambiri zowononga tizilombo toyambitsa matenda, kuphatikizapo kachilombo ka yellow fever, encephalomyelitis virus, Rift Valley fever virus, avian influenza virus, hepatitis virus, AIDS, phazi ndi pakamwa. matenda HIV, conjunctivitis HIV, yosavuta zidzolo kachilombo, Mengo virus, pox HIV, myocarditis HIV, Aleutian HIV, coxsackievirus, etc. Zatsimikiziridwa kuti njira yodzitetezera ya Polymyxa ndi bwino kuposa achire zotsatira za HIV matenda.
Kugwiritsa ntchito
1.Homopolymer yokhala ndi zingwe ziwiri zomwe zingagwiritsidwe ntchito ngati RNA yachitsanzo kuti iphunzire ma cell signing pamlingo wa TLR3 kuzindikira RNA yokhala ndi zingwe ziwiri, yomwe imathandizanso kwambiri chitetezo chamthupi ku tizilombo toyambitsa matenda.
2.Paired ndi asidi polyinosinic kupanga polyinosinic cell, ntchito zochizira matenda a chiwindi, nsungu zoster, nsungu simplex keratitis, nsungu stomatitis, mliri hemorrhagic fever, etc.
3. Iwo ali chitetezo adjuvant kwenikweni, kumapangitsa reticuloendothelial dongosolo, timapitiriza phagocytosis, timapitiriza antibody mapangidwe, kumapangitsa allograft anachita ndi kuchedwa thupi lawo siligwirizana.Iwo ali yotakata sipekitiramu antiviral kwenikweni ndi antitumor kwenikweni.Amagwiritsidwa ntchito kwambiri pochiza: kupewa kapena kuchiza matenda a virus, chithandizo cha nsungu zoster, herpetic keratitis, viral hepatitis.Adjuvant chithandizo cha zotupa.Zotsatira zoyipa zimaphatikizanso kuchepa kwa kutentha kwapang'onopang'ono komanso kutentha kwambiri kwa thupi kupitilira 38 ℃, komwe kumachepa kokha mkati mwa masiku 1-2.Ngati kutentha thupi sikuchepa mkati mwa masiku awiri, mankhwalawa ayenera kusiyidwa nthawi yomweyo.Kufooka, pakamwa youma, chizungulire, nseru, etc.
