Zogulitsa
Bucladesine
Zomangamanga Formula
Zakuthupi
Maonekedwe: Zinthu zoyera zolimba zopanda pake
Kusungirako: -20°C
Kusungunuka kwa H2O: 50 mg/mL
Data Data
Ndi katundu wamba
Kugwiritsa ntchito
Dibutyryl cyclic adenosine monophosphate sodium ndi yochokera ku cyclic adenosine monophosphate, yomwe imagwiritsidwa ntchito pochiza cardiogenic shock ndi kulephera kwa mtima.Mu 1999, mafuta a Dibutyryl cyclic adenosine monophosphate sodium adapangidwa kuti azichiza matenda a pakhungu ndi zilonda zapakhungu.
Kukonzekera sodium dibutyryl cyclophosphate adenosine: Mu botolo munali cyclophosphate adenosine pang`onopang`ono kuwonjezera amadzimadzi sodium hydroxide solution (3 mol/L) dropwise, ndondomeko kulamulira kutentha, dropwise anamaliza kutentha kwa firiji, kusintha pH kwa 7 ~ 8 ndi HCl yankho ( 20%), kuwonjezera anhydrous Mowa mpweya mpweya woyera olimba, kusefera, kuyanika kupeza woyera olimba sodium mchere;mchere wa sodium ndi n-butyl anhydride pansi pa chitetezo cha kutentha kwa N2 mpaka 140 ℃ reaction.Kuwunika kwa TLC, momwe zimakhalira ndikutsitsidwa kutentha, pang'onopang'ono onjezerani methyl tert-butyl ether, njira yokondoweza mwamphamvu, Chemicalbook kuti mupeze pafupifupi yoyera yolimba yakuda.Chisakanizo cha methyl tert-butyl ether ndi acetone adayimitsidwanso kuti apeze chinthu chandandale cha ufa woyera.Biological activityDibutyryl-cAMP(Bucladesine,dbcAMP) ndi cell-permeable PKA activator yomwe imachita potengera endogenous cAMP.Dibutyryl-cAMP(Bucladesine) ndi phosphodiesterase(PDE) inhibitor.
Maphunziro a in vitro: Dibutyryl-cAMP imaletsa kutengeka kwa shuga wa neuronal kudzera mu kuyambitsa kwa PKA.Mu hepatocytes ya makoswe otukuka, Dibutyryl-cAMP imalepheretsa mawu opangidwa ndi nitric oxide synthase ndi ntchito yomanga ya NF-kappaB.dibutyrChemicalbookyl-cAMP imalepheretsanso TNFalpha-induced rod cell apoptosis poletsa kuwongolera kwa FADD.
Maphunziro a vivo: Muchitsanzo cha mbewa, Bucladesine (600nM/mbewa, ip) inatembenuza zinc chloride ndi lead acetate induced evasive memory memory memory.
