Zogulitsa
5-Fluorocytosine
Zomangamanga Formula
Zakuthupi
Maonekedwe: ufa woyera
Kachulukidwe: 1.3990 (chiyerekezo)
Malo osungunuka: 298-300 °C (dec.) (lit.)
Malo otentha.
Refractivity
Pophulikira.
Data Data
Gulu lowopsa.
Nambala Yoyendetsa Katundu Woopsa.
Wonyamula gulu.
Kugwiritsa ntchito
Flucytosine pakamwa amagwiritsidwa ntchito pochiza matenda aakulu omwe amayamba chifukwa cha tizilombo toyambitsa matenda a Candida kapena Cryptococcus neoformans.Itha kugwiritsidwanso ntchito pochiza chromomycosis (chromoblastomycosis), ngati zovuta zomwe zingayambitse matendawa.Flucytosine sayenera kugwiritsidwa ntchito ngati wothandizira yekha pachiwopsezo cha matenda mafangasi chifukwa ndi ofooka zotsatira antifungal ndi kusala kudya kukana, koma osakaniza amphotericin B ndi/kapena azole antifungals monga fluconazole kapena itraconazole.Matenda aang'ono monga candidal cystitis akhoza kuchiritsidwa ndi flucytosine yokha.M'mayiko ena, chithandizo chapang'onopang'ono mtsempha wamagazi osapitirira sabata ndi njira yochizira, makamaka ngati matendawa ali pachiwopsezo.
Matenda owopsa a fungal amatha kuchitika mwa omwe alibe chitetezo chamthupi.Anthuwa amapindula ndi mankhwala ophatikiza kuphatikiza flucytosine, koma kuchuluka kwa zotsatira za mankhwala ophatikiza, makamaka amphotericin B, kungakhale kokwera.
5-Fluorocytosine amagwiritsidwa ntchito pochiza matenda oyamba ndi fungus omwe amayamba chifukwa cha Cryptococcus ndi Candida, monga fungal sepsis, endocarditis, meningitis, ndi antifungal agents pamatenda am'mapapo ndi mkodzo.
Khalidwe
Chogulitsachi chimakhala ndi zochita zambiri za antifungal motsutsana ndi Candida spp.ndi Candida spp.komanso ali ndi antibacterial zochita motsutsana ndi Bacillus spp.ndi Mycobacterium spp.The mankhwala ndi antibacterial pa otsika ndende ndi fungicidal pa mkulu ndende.Limagwirira ntchito ndi kutsekereza synthesis wa fungal nucleic acid.Bowa ndi losavuta kutulutsa kukana kwa mankhwalawa.
Kusamalitsa
Kuphatikizidwa ndi amphotericin B, imakhala ndi synergistic kwenikweni, koma imatha kuchepetsa kutuluka kwa mankhwalawa kuchokera ku impso ndikuwonjezera kuchuluka kwa magazi, zomwe zingayambitse poizoni mu impso ndi magazi.Choncho, chiwerengero chapamwamba cha magazi chiyenera kuyang'aniridwa ndi kusungidwa pa 50-75μg / ml, osapitirira 100μg / ml;kugwiritsa ntchito zoletsa m`mafupa akhoza kuonjezera hematologic kawopsedwe cha mankhwala.
Izi zitha kuyambitsa ① nseru, kutsekula m'mimba, zidzolo, etc.;② chiwindi kuwonongeka, makamaka okwera chiwindi ntchito zizindikiro, komanso hepatomegaly kapena kwa chiwindi necrosis;③ myelosuppression leukocyte ndi kuchepetsa kupatsidwa zinthu za m`mwazi, nthawi zina kungayambitse magazi athunthu cytopenia.Kuperewera kwakupha kwa granulocytic leukocyte ndi kutaya magazi m'thupi kwanenedwanso;④ kuyerekezera zinthu m'maganizo, mutu ndi vertigo zanenedwanso.Choncho, ntchito mosamala odwala kwa chiwindi kapena aimpso kuwonongeka, magazi matenda, ndi m`mafupa kupondereza.Chithunzi chamagazi, chiwindi ndi impso ndi machitidwe a mkodzo ziyenera kuyang'aniridwa pafupipafupi mukamagwiritsa ntchito mankhwalawa.Ili ndi mphamvu ya teratogenic pakuyesa nyama, ndipo iyenera kugwiritsidwa ntchito mosamala kwa amayi apakati.
Zotsatira zoyipa zimaphatikizapo kuchuluka kwa transaminase, alkaline phosphatase, zizindikiro za m'mimba, leukopenia, kuchepa magazi, thrombocytopenia, kuwonongeka kwa aimpso, kupweteka mutu, kuchepa kwa maso, kuyerekezera zinthu m'maganizo, kumva, dyskinesia, kuchepa kwa seramu potaziyamu, calcium ndi phosphorous, ndi zotupa (mwachitsanzo, zotupa). .
