3,3'- diindolylmethane

Kufotokozera Kwachidule:

3,3'- diindolylmethane (3,3'-diindolylmethane) ndi woyera pafupifupi woyera crystalline ufa, amene sungunuka mu methanol, ethyl acetate, dichloromethane ndi zina zosungunulira organic.3,3'- diindole methane imapezeka kwambiri muzomera zachilengedwe za Cruciferae.Lili ndi zofunikira zamoyo ndi zamankhwala ndipo zimagwiritsidwa ntchito kwambiri pazamankhwala ndi zamankhwala.3,3'-diindolylmethane (DIM) ndiye chinthu chachikulu cham'mimba cha indole-3-carbinol, chomwe ndi chinthu chothana ndi khansa m'masamba a cruciferous.3,3'-diindolylmethane (DIM) ndi mdani wamphamvu wa cholandilira choyera cha Android (AR).

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

Kufotokozera

3,3'-diindolylmethane ndi mankhwala apakatikati;Zitha kupezeka mu phytochemicals zachilengedwe za Cruciferae Plants, acid catalyzed reaction products, indole-3-methanol;Ili ndi ntchito ya anti-chotupa wothandizira;Pansi pa chikhalidwe chapamwamba ndende, zotumphukira sizingangowonjezera mwachindunji apoptosis ya maselo a khansa ya munthu, komanso kulimbikitsa njira kuti ipangitse apoptosis ya maselo a khansa;Chemicalbookdim imapangitsa G1 cell ring inhibition m'maselo a khansa ya m'mawere a MCF-7 kudzera mu makina ndi kufotokozera;Dim ndi inhibitor yamphamvu ya mitochondrial h + -atpase;Monga cholimbikitsa kukula kwa mbewu, dim ndi zotuluka zake zakhala zikugwiritsidwa ntchito pofufuza zamakina ochezeka.

Zambiri Zamalonda

Cas No.: 1968-05-4

Chiyero: ≥98%

Mtengo wa C17H14N2

Fomula Wt.Mtundu: 246.31

Dzina la Chemical: 3,3'-Diindolylmethane

Mawu ofanana ndi mawu : :3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Chomera:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE

Malo osungunuka: 167 ° C

Malo otentha: 230 ° C

Kusungunuka: Chloroform (Mochepa), Methanol (Pang'ono)

Maonekedwe: ufa wopanda woyera

Kutumiza ndi Kusunga

Kukhazikika kosungirako Kufunika kosungirako kutentha -20°C.

Kukonzekera Ikani indole (1.17 g, 10 mmol), CTAB (50% mol) ndi oxalic acid (50% mol) mu botolo la 25 ml la khosi limodzi lozungulira-pansi, onjezerani 5 ml madzi osakanizidwa, gwedezani bwino kwa mphindi zisanu kenako. Onjezani yankho lamadzi la formaldehyde (0.38 g yankho, 5 mmol formaldehyde) dropwise.Bweretsani kwa maola atatu kutentha kwa chipinda ndikuyimitsa zomwe zikuchitika.The njira yothetsera anali yotengedwa ndi 15 ml ya ethyl acetate mu magawo atatu, ndi organic gawo linasonkhanitsidwa ndi zouma ndi anhydrous Na2SO4 kwa 5 hours.Chosungunuliracho chinachotsedwa pansi pa kupanikizika kocheperapo ndikutsitsimutsidwanso kuchokera ku chisakanizo cha methanol ndi madzi (methanol / H2ChemicalbookO = 10/1) kuti apereke woyera olimba 3,3'-diindolylmethane mu 85% zokolola.Bioactivity3,3'-Diindolylmethane (DIM) ndiye chinthu chachikulu cha digestion cha indole-3-carbinol, chomwe chimakhala chotsutsana ndi khansa mu masamba a cruciferous. .
Kafukufuku wa in vitro wasonyeza kuti DIM ndi radioprotector yothandiza komanso yochepetsera, ikuchita mwa kulimbikitsa mayankho a DDR oyendetsedwa ndi ATM komanso NF-κB kupulumuka chizindikiro.DIM ikhoza kulepheretsa kufalikira kwa maselo a chotupa, angiogenesis, kufalikira ndi kuyambitsa apoptosis mwa kusintha njira zowonetsera. monga AKT, NF-κB ndi FOXO3.Ikhozanso kulepheretsa estrogen-induced gene expression ndi kuyambitsa endoplasmic reticulum stress.ChemicalbookDIM imatha kusintha kagayidwe ka estrogen ndikusokoneza ntchito ya estrogen ndi androgen receptor.Kafukufuku wa mu vivo awonetsa kuti DIM imagwira ntchito motsutsana ndi ma radiation a systemic pambuyo pa machitidwe angapo.M'mayeso a vivo, DIM idapereka chitetezo kapena kuchepetsa ma radiation.M'magulu abwinobwino, DIM imayambitsa ATM.diM ikhoza kuperekedwa kwa mbewa podzaza pakamwa (250 mg/kg) yokhala ndi bioavailability yayikulu komanso yopanda t pachimake.

Zam'mbuyo: China Indole Manufacture Supplier

Ena: China Indole-3-methanol Manufacture Supplier